Plasma malondialdehyde: a poor measure of in vivo lipid peroxidation.
نویسندگان
چکیده
منابع مشابه
evaluation of lipid peroxidation as an indirect measure of oxidative stress in seminal plasma
background: it has been proposed that oxidative stress plays an important role in male infertility. the aims of this study were to compare seminal plasma levels of 15-f2t-isoprostane (8-iso-pgf2?), malondialdehyde (mda), and total (sum of free and bound) homocysteine (thcy) in normozoospermic vs. asthenozoospermic men, and to examine the relationships between thcy and lipid peroxidation product...
متن کاملAssociation between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation.
Evidence suggests that low serum enterolactone concentration might be an independent risk factor for acute coronary events. Enterolactone is a lignan, which is formed by intestinal bacteria from precursors in plant foods. Due to the biphenolic structure of enterolactone, it could act as an antioxidant and through this contribute to cardiovascular health. The aim of this study was to test the hy...
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Malondialdehyde (MDA) is an endogenous genotoxic product of enzymatic and oxygen radical-induced lipid peroxidation whose adducts are known to exist in DNA isolated from healthy human beings. To evaluate the mutagenic potential of MDA in human cells, we reacted MDA with pSP189 shuttle vector DNA and then transfected them into human fibroblasts for replication. MDA induced up to a 15-fold increa...
متن کاملEnhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels.
An elevated plasma total homocysteine level (tHcy) is considered an independent risk factor for atherosclerosis. The mechanisms by which hyperhomocysteinemia induces atherosclerosis are only partially understood, but promotion of LDL oxidation and endothelial injury have been suggested. The purpose of this study was to test the hypothesis that a high plasma tHcy is associated in men with increa...
متن کاملBlood lipid peroxidation (superoxide dismutase, malondialdehyde, glutathione) levels in Egyptian type 2 diabetic patients.
INTRODUCTION The existence of hyperglycaemia produces increased oxidative stress. The depletion of antioxidants as a defensive body mechanism may increase the risk of diabetic complications. Diabetes mellitus is associated with derangements in the serum levels of several biochemical parameters, and type 2 diabetes mellitus (or non-insulin-dependent diabetes mellitus) is a risk factor for cardio...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1988
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/34.1.208